Jefferis, B.J.;
Whincup, P.;
Welsh, P.;
Wannamethee, G.;
Rumley, A.;
Lennon, L.;
Thomson, A.;
... Lowe, G.; + view all
(2010)
Prospective study of matrix metalloproteinase-9 and risk of myocardial infarction and stroke in older men and women.
Atherosclerosis
, 208
(2)
pp. 557-563.
10.1016/j.atherosclerosis.2009.08.018.
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Abstract
OBJECTIVES: The endopeptidase matrix metalloproteinase-9 (MMP-9) is implicated in atherosclerotic plaque rupture. We investigate prospective associations between MMP-9 and MI or stroke in an older general population cohort, accounting for established and novel cardiovascular risk factors. METHODS: Baseline serum MMP-9 was measured in incident MI (n=368) and stroke (n=299) cases and two controls per case, 'nested' in prospective studies of 4252 men and 4286 women aged 60-79 years, sampled from General Practices in Britain in 1998-2000, with 7-year follow-up for fatal and non-fatal MI and stroke. RESULTS: Geometric mean MMP-9 was 528ng/mL (IQR 397, 743) in MI cases compared to 501ng/mL (IQR 370, 743) in controls, p=0.10. Participants in the top compared to bottom third of MMP-9 levels had an age-adjusted odds ratio for MI of 1.53 (95% CI 1.09, 2.13), which attenuated to 1.18 (95% CI 0.81, 1.70) after adjustment for established and novel cardiovascular risk factors. There was weak evidence that OR differed according to pre-existing CVD; the OR for MI in 187 participants with pre-existing CVD was 2.20 (1.04, 4.64) and 1.24 (0.84, 1.82) in 715 participants without (LR test for interaction p=0.06). Geometric mean MMP-9 levels were higher in stroke cases than controls; 522ng/mL (IQR 363, 673) vs 487 (IQR 393, 704), p=0.045; however adjustments similarly attenuated the associations. CONCLUSIONS: While serum MMP-9 is univariately associated with risk of MI and stroke, it is not a strong independent risk marker for either.
| Type: | Article |
|---|---|
| Title: | Prospective study of matrix metalloproteinase-9 and risk of myocardial infarction and stroke in older men and women |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.atherosclerosis.2009.08.018 |
| Publisher version: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC282295... |
| Language: | English |
| Keywords: | Myocardial infarction, Stroke, Inflammation, Epidemiology, MMP-9, Prospective, Cohort, CORONARY-ARTERY-DISEASE, CARDIOVASCULAR-DISEASE, PLASMA MATRIX-METALLOPROTEINASE-9, SERUM MATRIX-METALLOPROTEINASE-9, MATRIX METALLOPROTEINASES, HEART-DISEASE, SUSCEPTIBILITY, LEVEL |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Primary Care and Population Health |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/18274 |
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