Caulfield, MJ;
Munroe, PB;
O'Neill, D;
Witkowska, K;
Charchar, FJ;
Doblado, M;
Evans, S;
... Cheeseman, C; + view all
(2008)
SLC2A9 is a high-capacity urate transporter in humans.
PLoS Medicine
, 5
(10)
, Article e197. 10.1371/journal.pmed.0050197.
![[thumbnail of journal.pmed.0050197.pdf]](https://discovery-pp.ucl.ac.uk/style/images/fileicons/application_pdf.png) Preview |
PDF
journal.pmed.0050197.pdf Download (495kB) |
Abstract
Serum uric acid levels in humans are influenced by diet, cellular breakdown, and renal elimination, and correlate with blood pressure, metabolic syndrome, diabetes, gout, and cardiovascular disease. Recent genome-wide association scans have found common genetic variants of SLC2A9 to be associated with increased serum urate level and gout. The SLC2A9 gene encodes a facilitative glucose transporter, and it has two splice variants that are highly expressed in the proximal nephron, a key site for urate handling in the kidney. We investigated whether SLC2A9 is a functional urate transporter that contributes to the longstanding association between urate and blood pressure in man.
| Type: | Article |
|---|---|
| Title: | SLC2A9 is a high-capacity urate transporter in humans |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pmed.0050197 |
| Publisher version: | http://dx.doi.org/10.1371/journal.pmed.0050197 |
| Language: | English |
| Additional information: | © 2008 Caulfield et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/61509 |
Archive Staff Only
 |
View Item |
