Janes, SM;
Watt, FM;
(2004)
Switch from alpha v beta 5 to alpha v beta 6 integrin expression protects squamous cell carcinomas from anoikis.
J CELL BIOL
, 166
(3)
419 - 431.
10.1083/jcb.200312074.
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Abstract
Stratified squamous epithelia express the alphavbeta5 integrin, but in squamous cell carcinomas (SCCs) there is down-regulation of alphavbeta5 and up-regulation of alphavbeta6. To investigate the significance of this finding, we transduced an alphav-negative human SCC line with retroviral vectors encoding alphav integrins. alphavbeta5-expressing cells underwent suspension-induced apoptosis (anoikis), whereas alpha-negative cells and cells expressing alphavbeta6 did not. Resistance to anoikis correlated with PKB/Akt activation in suspension, but not with changes in PTEN or p110alpha P13 kinase levels.
| Type: | Article |
|---|---|
| Title: | Switch from alpha v beta 5 to alpha v beta 6 integrin expression protects squamous cell carcinomas from anoikis |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1083/jcb.200312074 |
| Keywords: | keratinocyte, apoptosis, differentiation, Akt, extracellular matrix, HUMAN EPIDERMAL-KERATINOCYTES, DETACHMENT-INDUCED APOPTOSIS, AKT/PROTEIN KINASE-B, NF-KAPPA-B, TERMINAL DIFFERENTIATION, INTEGRIN EXPRESSION, SUBCELLULAR-LOCALIZATION, SURVIVAL SIGNALS, BETA-6 INTEGRIN, CANCER CELLS |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/6897 |
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