Guerreiro, RJ;
Gustafson, DR;
Hardy, J;
(2012)
The genetic architecture of Alzheimer's disease: beyond APP, PSENs and APOE.
Neurobiology of Disease
, 33
(3)
437 - 456.
10.1016/j.neurobiolaging.2010.03.025.
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Abstract
Alzheimer's disease (AD) is a complex disorder with a clear genetic component. Three genes have been identified as the cause of early onset familial AD (EOAD). The most common form of the disease, late onset Alzheimer's disease (LOAD), is, however, a sporadic one presenting itself in later stages of life. The genetic component of this late onset form of AD has been the target of a large number of studies, because only one genetic risk factor (APOE4) has been consistently associated with the disease. However, technological advances allow new approaches in the study of complex disorders. In this review, we discuss the new results produced by genome wide association studies, in light of the current knowledge of the complexity of AD genetics.
| Type: | Article |
|---|---|
| Title: | The genetic architecture of Alzheimer's disease: beyond APP, PSENs and APOE. |
| Location: | US |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.neurobiolaging.2010.03.025 |
| Publisher version: | http://dx.doi.org/10.1016/j.neurobiolaging.2010.03... |
| Language: | English |
| Additional information: | This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. PMCID: PMC2980860 |
| Keywords: | Alzheimer Disease, Amyloid beta-Protein Precursor, Animals, Apolipoproteins E, Humans, Presenilin-1, Presenilin-2 |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/741327 |
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