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Allergic skin rash with lamotrigine and concomitant valproate therapy - Evidence for an increased risk

Li, LM; Russo, M; ODonoghue, MF; Duncan, JS; Sander, JWAS; (1996) Allergic skin rash with lamotrigine and concomitant valproate therapy - Evidence for an increased risk. ARQ NEURO-PSIQUIAT , 54 (1) 47 - 49. 10.1590/S0004-282X1996000100008. Green open access

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Abstract

Cutaneous rash is one of the commonest adverse events associated with lamotrigine. We assessed whether the risk is increased in patients receiving concomitant valproate therapy in a population of 103 adult patients with intractable epilepsy, who had lamotrigine added to their treatment. Of the 33 patients taking valproate, 10 (30%) developed a rash, whilst of the 70 not taking valproate, only 6 (8%) developed a rash. This suggests a significantly higher risk of cutaneous rash when starting lamotrigine in patients already taking valproate (p<0.02).

Type: Article
Title: Allergic skin rash with lamotrigine and concomitant valproate therapy - Evidence for an increased risk
Open access status: An open access version is available from UCL Discovery
DOI: 10.1590/S0004-282X1996000100008
Publisher version: http://dx.doi.org/10.1590/S0004-282X1996000100008
Language: English
Additional information: All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License.
Keywords: allergic skin rash, antiepileptic drugs, lamotrigine, valproate
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy
URI: https://discovery-pp.ucl.ac.uk/id/eprint/81207
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