Vergallo, A;
Bun, R-S;
Toschi, N;
Baldacci, F;
Zetterberg, H;
Blennow, K;
Cavedo, E;
... Alzheimer Precision Medicine Initiative (APMI); + view all
(2018)
Association of Cerebrospinal Fluid Α-synuclein With Total and Phospho-tau181 Protein Concentrations and Brain Amyloid Load in Cognitively Normal Subjective Memory Complainers Stratified by Alzheimer's Disease Biomarkers.
Alzheimers Dement
, 14
(12)
pp. 1623-1631.
10.1016/j.jalz.2018.06.3053.
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Abstract
INTRODUCTION: Several neurodegenerative brain proteinopathies, including Alzheimer's disease (AD), are associated with cerebral deposition of insoluble aggregates of α-synuclein. Previous studies reported a trend toward increased cerebrospinal fluid (CSF) α-synuclein (α-syn) concentrations in AD compared with other neurodegenerative diseases and healthy controls. METHODS: The pathophysiological role of CSF α-syn in asymptomatic subjects at risk of AD has not been explored. We performed a large-scale cross-sectional observational monocentric study of preclinical individuals at risk for AD (INSIGHT-preAD). RESULTS: We found a positive association between CSF α-syn concentrations and brain β-amyloid deposition measures as mean cortical standard uptake value ratios. We demonstrate positive correlations between CSF α-syn and both CSF t-tau and p-tau181 concentrations. DISCUSSION: Animal models presented evidence, indicating that α-syn may synergistically and directly induce fibrillization of both tau and β-amyloid. Our data indicate an association of CSF α-syn with AD-related pathophysiological mechanisms, during the preclinical phase of the disease.
| Type: | Article |
|---|---|
| Title: | Association of Cerebrospinal Fluid Α-synuclein With Total and Phospho-tau181 Protein Concentrations and Brain Amyloid Load in Cognitively Normal Subjective Memory Complainers Stratified by Alzheimer's Disease Biomarkers |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.jalz.2018.06.3053 |
| Publisher version: | https://doi.org/10.1016/j.jalz.2018.06.3053 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Alzheimer's disease, Amyloid PET, Cerebrospinal fluid, Monocentric, Preclinical, SUVR, Subjective memory complainers, Synergistic, Tau protein, α-Synuclein |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10059341 |
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