UCL Discovery Stage
UCL home » Library Services » Electronic resources » UCL Discovery Stage

The potential anti-infective applications of metal oxide nanoparticles: A systematic review

Abo-zeid, Y; Williams, G; (2020) The potential anti-infective applications of metal oxide nanoparticles: A systematic review. WIREs Nanomedicine and Nanobiotechnology , 12 (2) , Article e1592. 10.1002/wnan.1592. Green open access

[thumbnail of Williams_The potential anti-infective applications of metal oxide nanoparticles. A systematic review_AAM.pdf]
Preview
Text
Williams_The potential anti-infective applications of metal oxide nanoparticles. A systematic review_AAM.pdf - Accepted Version

Download (2MB) | Preview

Abstract

Microbial infections present a major global healthcare challenge, in large part because of the development of microbial resistance to the currently approved antimicrobial drugs. This demands the development of new antimicrobial agents. Metal oxide nanoparticles (MONPs) are a class of materials that have been widely explored for diagnostic and therapeutic purposes. They are reported to have wide‐ranging antimicrobial activities and to be potent against bacteria, viruses, and protozoans. The use of MONPs reduces the possibility of resistance developing because they have multiple mechanisms of action (including via reactive oxygen species generation), simultaneously attacking many sites in the microorganism. However, despite this there are to date no MONPs clinically approved for antimicrobial therapy. This review explores the recent literature in this area, discusses the mechanisms of MONP action against microorganisms, and considers the barriers faced to the use of MONPs in humans. These include biological challenges, of which the potential for an immune response and off‐target toxicity are key. We explore in detail the possible benefits/disbenefits of an immune response being initiated, and consider the effect of production method (chemical vs. green synthesis) on cytotoxicity. There are also a number of technical and manufacturing challenges hindering MONP translation to the clinic which are additionally discussed in depth. In the short term, there are potentially some “quick wins” from the repurposing of already‐approved nanoparticle‐based medicines for anti‐infective applications, but a number of hurdles, both technical and biological, lie in the path to long‐term clinical translation of new MONP‐based formulations. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease Therapeutic Approaches and Drug Discovery > Emerging Technologies Toxicology and Regulatory Issues in Nanomedicine > Toxicology of Nanomaterials

Type: Article
Title: The potential anti-infective applications of metal oxide nanoparticles: A systematic review
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/wnan.1592
Publisher version: https://doi.org/10.1002/wnan.1592
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
URI: https://discovery-pp.ucl.ac.uk/id/eprint/10082408
Downloads since deposit
Loading...
44,034Downloads
Download activity - last month
Loading...
Download activity - last 12 months
Loading...
Downloads by country - last 12 months
1.India
12
2.United States
10
3.China
8
4.Iran, Islamic Republic of
6
5.South Africa
3
6.Iraq
3
7.Pakistan
3
8.Egypt
2
9.Germany
2
10.Canada
2

Archive Staff Only

View Item View Item