Whitehead, K;
Jones, L;
Laudiano-Dray, MP;
Meek, J;
Fabrizi, L;
(2019)
Event-related potentials following contraction of respiratory muscles in pre-term and full-term infants.
Clinical Neurophysiology
, 130
(12)
pp. 2216-2221.
10.1016/j.clinph.2019.09.008.
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Abstract
Objective: Involuntary isolated body movements are prominent in pre-term and full-term infants. Proprioceptive and tactile afferent feedback following limb muscle contractions is associated with somatotopic EEG responses. Involuntary contractions of respiratory muscles, primarily the diaphragm – hiccups – are also frequent throughout the human perinatal period during active behavioural states. Here we tested whether diaphragm contraction provides afferent input to the developing brain, as following limb muscle contraction. / Methods: In 13 infants on the neonatal ward (30–42 weeks corrected gestational age), we analysed EEG activity (18-electrode recordings in six subjects; 17-electrode recordings in five subjects; 16-electrode recordings in two subjects), time-locked to diaphragm contractions (n = 1316) recorded with a movement transducer affixed to the trunk. / Results: All bouts of hiccups occurred during wakefulness or active sleep. Each diaphragm contraction evoked two initial event-related potentials with negativity predominantly across the central region, and a third event-related potential with positivity maximal across the central region. / Conclusions: Involuntary contraction of the diaphragm can be encoded by the brain from as early as ten weeks prior to the average time of birth. / Significance: Hiccups – frequently observed in neonates – can provide afferent input to developing sensory cortices in pre-term and full-term infants.
| Type: | Article |
|---|---|
| Title: | Event-related potentials following contraction of respiratory muscles in pre-term and full-term infants |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.clinph.2019.09.008 |
| Publisher version: | https://doi.org/10.1016/j.clinph.2019.09.008 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Somatosensory, Proprioceptive, Afferent, Diaphragm, Hiccup, Evoked potential |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Neonatology |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10085852 |
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