Carreno, G;
Guiho, R;
Martinez-Barbera, JP;
(2021)
Cell Senescence in Neuropathology: a Focus on Neurodegeneration and Tumours.
Neuropathology and Applied Neurobiology
, 47
(3)
pp. 359-378.
10.1111/nan.12689.
Preview |
Text
Guiho_nan.12689.pdf - Published Version Download (1MB) | Preview |
Abstract
The study of cell senescence is a burgeoning field. Senescent cells can modify the cellular microenvironment through the secretion of a plethora of biologically active products referred to as the senescence‐associated secretory phenotype (SASP). The consequences of these paracrine signals can be either beneficial for tissue homeostasis, if senescent cells are properly cleared and SASP activation is transient, or result in organ dysfunction, when senescent cells accumulate within the tissues and SASP activation is persistent. Several studies have provided evidence for a role of senescence and SASP in promoting age‐related diseases or driving organismal ageing. The hype about senescence has been further amplified by the fact that a group of drugs, named senolytics, have been used to successfully ameliorate the burden of age‐related diseases and increase health and life span in mice. Ablation of senescent cells in the brain prevents disease progression and improve cognition in murine models of neurodegenerative conditions. The role of senescence in cancer has been more thoroughly investigated, and it is now accepted that senescence is a double‐edged sword that can paradoxically prevent or promote tumourigenesis in a context dependent manner. In addition, senescence induction followed by senolytic treatment is starting to emerge as a novel therapeutic avenue that could improve current anti‐cancer therapies and reduce tumour recurrence. In this review, we discuss recent findings supporting a role of cell senescence in the pathogenesis of neurodegenerative diseases and in brain tumours. A better understanding of senescence is likely to result in the development of novel and efficacious anti‐senescence therapies against these brain pathologies.
| Type: | Article |
|---|---|
| Title: | Cell Senescence in Neuropathology: a Focus on Neurodegeneration and Tumours |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/nan.12689 |
| Publisher version: | https://doi.org/10.1111/nan.12689 |
| Language: | English |
| Additional information: | This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Cell senescence, SASP, senolytic, Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, craniopharyngioma, low-grade glioma, glioblastoma multiforme, medulloblastoma, diffuse midline glioma |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10118955 |
Archive Staff Only
 |
View Item |
