Stamatakis, M;
Adams, R;
Balázsi, G;
(2009)
A Common Repressor Pool Results in Indeterminacy of Extrinsic Noise.
In:
Proceedings Foundations of Systems Biology and Engineering (FOSBE 2009).
FOSBE - Foundations of Systems Biology in Engineering
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Abstract
For over a decade, noise in gene expression has been the focus of experimental and theoretical studies. It is currently accepted that gene expression noise can be decomposed into extrinsic and intrinsic components, which have orthogonal contributions to the total noise. Intrinsic noise stems from the random occurrence of biochemical reactions and is inherent to gene expression. Extrinsic noise originates from fluctuations in the concentrations of regulatory components or random transitions in the cell’s state and is imposed to the gene of interest by the intra- and extra-cellular environment. The basic assumption has been that extrinsic noise acts as a pure input on the gene of interest, which exerts no feedback on the extrinsic noise source. Consequently, multiple copies of a gene would be uniformly influenced by an extrinsic noise source. Here we report that this assumption falls short when multiple genes share a common pool of a regulatory molecule. Due to competitive utilization of the molecules existing in this pool, genes are no longer uniformly influenced by the extrinsic noise source. Rather, they exert negative feedbacks on each other. Thus, extrinsic noise calculated using the currently established method becomes ill-defined.
| Type: | Proceedings paper |
|---|---|
| Title: | A Common Repressor Pool Results in Indeterminacy of Extrinsic Noise |
| Event: | FOSBE 2009: The 3rd Third International Conference on Foundations of Systems Biology in Engineering |
| Location: | Denver, CO, USA |
| Open access status: | An open access version is available from UCL Discovery |
| Publisher version: | http://fosbe.org/ |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Two promoter system, Intrinsic noise, Extrinsic noise, Indeterminacy, Chemical Master Equation, Negative feedback, Stochastic gene expression. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Chemical Engineering |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10133576 |
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