Veighey, K;
MacAllister, R;
(2015)
Clinical applications of remote ischaemic preconditioning in native and transplant acute kidney injury.
Pediatric Nephrology
, 30
(10)
pp. 1749-1759.
10.1007/s00467-014-2965-6.
![[thumbnail of art_10.1007_s00467-014-2965-6.pdf]](https://discovery-pp.ucl.ac.uk/style/images/fileicons/application_pdf.png) Preview |
PDF
art_10.1007_s00467-014-2965-6.pdf Download (382kB) |
Abstract
Ischaemia-reperfusion (IR) injury is a composite of the injury sustained during a period of reduced or absent blood flow to a tissue or organ and the additional insult sustained upon reperfusion that limits the amount of tissue that can be salvaged. IR injury plays a central role in both native and transplant acute kidney injury (AKI). Native AKI is associated with increased morbidity and mortality in hospital inpatients, and transplant AKI contributes to graft dysfunction, ultimately limiting graft longevity. In this review, we discuss the potential therapeutic benefits of a cost-effective and low-risk intervention, remote ischaemic preconditioning (RIPC), and its applicability in the prevention and reduction of AKI.
| Type: | Article |
|---|---|
| Title: | Clinical applications of remote ischaemic preconditioning in native and transplant acute kidney injury |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s00467-014-2965-6 |
| Publisher version: | http://dx.doi.org/10.1007/s00467-014-2965-6 |
| Language: | English |
| Additional information: | This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
| Keywords: | Ischaemia–reperfusion, Acute kidney injury, Transplantation, Remote ischaemic preconditioning, Therapeutic benefits |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1450374 |
Archive Staff Only
 |
View Item |
