García-Gareta, E;
Davidson, C;
Levin, A;
Coathup, MJ;
Blunn, GW;
(2016)
Biofilm formation in total hip arthroplasty: Prevention and treatment.
RSC Advances
, 6
(83)
pp. 80244-80261.
10.1039/c6ra09583f.
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Abstract
Biomaterials science is a very active area of research, which has allowed the successful use of implants in the orthopaedic field for over a century. However, implant infection remains a clinical concern as it is associated with extensive patient morbidity and a high economic burden, which is predicted to increase due to an ageing population. Bacteria are able to adhere, colonise and develop into biofilms on the surface of biomaterials making associated infections physiologically different to other post-surgical infections. Unfortunately, biofilms exert increased protection from the host immune system and an increased resistance to antibiotic therapy in comparison to their planktonic counterparts. The aim of this review is to assess the current knowledge on treatments, pathogenesis and the prevention of infections associated with orthopaedic implants, with a focus on total hip arthroplasty.
| Type: | Article |
|---|---|
| Title: | Biofilm formation in total hip arthroplasty: Prevention and treatment |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1039/c6ra09583f |
| Publisher version: | http://doi.org/10.1039/c6ra09583f |
| Language: | English |
| Additional information: | This journal is © The Royal Society of Chemistry 2016. This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1551196 |
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