Browse by UCL Departments and Centres
Group by: Author | Type
Number of items: 121.
A
Akbar, AN;
Gilroy, DW;
(2020)
Aging immunity may exacerbate COVID-19.
Science
, 369
(6501)
pp. 256-257.
10.1126/science.abb0762.
|
Armeni, E;
Aziz, U;
Qamar, S;
Nasir, S;
Nethaji, C;
Negus, R;
Murch, N;
... Karra, E; + view all
(2020)
Protracted ketonaemia in hyperglycaemic emergencies in COVID-19: a retrospective case series.
The Lancet Diabetes & Endocrinology
, 8
(8)
pp. 660-663.
10.1016/S2213-8587(20)30221-7.
|
Armstrong, RA;
Davey, T;
Allsopp, AJ;
Lanham-New, SA;
Oduoza, U;
Cooper, JA;
Montgomery, HE;
(2020)
Low serum 25-hydroxyvitamin D status in the pathogenesis of stress fractures in military personnel: An evidenced link to support injury risk management.
PLOS ONE
, 15
(3)
, Article e0229638. 10.1371/journal.pone.0229638.
|
Arulkumaran, N;
Brealey, D;
Howell, D;
Singer, M;
(2020)
Use of non-invasive ventilation for patients with COVID-19: a cause for concern?
The Lancet Respiratory Medicine
, 8
(6)
, Article e45. 10.1016/S2213-2600(20)30181-8.
|
Augusto, JB;
Menacho, K;
Andiapen, M;
Bowles, R;
Burton, M;
Welch, S;
Bhuva, AN;
... Moon, JC; + view all
(2020)
Healthcare Workers Bioresource: Study outline and baseline characteristics of a prospective healthcare worker cohort to study immune protection and pathogenesis in COVID-19 [version 1; peer review: 1 approved, 1 approved with reservations].
Wellcome Open Research
, 5
, Article 179. 10.12688/wellcomeopenres.16051.1.
|
Augusto, JB;
Menacho, K;
Andiapen, M;
Bowles, R;
Burton, M;
Welch, S;
Bhuva, AN;
... Moon, JC; + view all
(2020)
Healthcare Workers Bioresource: Study outline and baseline characteristics of a prospective healthcare worker cohort to study immune protection and pathogenesis in COVID-19 [version 2; peer review: 1 approved, 2 approved with reservations].
Wellcome Open Research
, 5
, Article 179. 10.12688/wellcomeopenres.16051.2.
|
B
Banerjee, G;
Ambler, G;
Keshavan, A;
Paterson, RW;
Foiani, MS;
Toombs, J;
Heslegrave, A;
... Werring, DJ; + view all
(2020)
Cerebrospinal fluid biomarkers in cerebral amyloid angiopathy.
Journal of Alzheimer's Disease
, 74
(4)
pp. 1189-1201.
10.3233/JAD-191254.
(In press).
|
Bhatnagar, G;
Quinn, L;
Higginson, A;
Plumb, A;
Halligan, S;
Tolan, D;
Lapham, R;
... METRIC study investigators; + view all
(2020)
Observer agreement for small bowel ultrasound in Crohn's disease: results from the METRIC trial.
Abdominal Radiology
10.1007/s00261-020-02405-w.
(In press).
|
Bhogal, P;
Jensen, M;
Hart, D;
Makalanda, L;
Collins, GB;
Spooner, O;
Jaffer, O;
(2020)
Von Willebrand factor.
Clinical Medicine
, 20
(6)
, Article e279. 10.7861/clinmed.let.20.6.3.
|
Bordes, J;
Incerti, S;
Mora‐Ramirez, E;
Tranel, J;
Rossi, C;
Bezombes, C;
Bordenave, J;
... Bordage, M; + view all
(2020)
Monte Carlo dosimetry of a realistic multicellular model of follicular lymphoma in a context of radioimmunotherapy.
Medical Physics
, 47
(10)
pp. 5222-5234.
10.1002/mp.14370.
|
Breen-Norris, JO;
Siow, B;
Walsh, C;
Hipwell, B;
Hill, I;
Roberts, T;
Hall, MG;
... Walker-Samuel, S; + view all
(2020)
Measuring diffusion exchange across the cell membrane with DEXSY (Diffusion Exchange Spectroscopy).
Magnetic Resonance in Medicine
10.1002/mrm.28207.
(In press).
|
Brown, A;
Dornhorst, A;
McGowan, B;
Omar, O;
Leeds, AR;
Taheri, S;
Frost, GS;
(2020)
Low-energy total diet replacement intervention in patients with type 2 diabetes mellitus and obesity treated with insulin: a randomized trial.
BMJ Open Diabetes Research and Care
, 8
(1)
, Article e001012. 10.1136/bmjdrc-2019-001012.
|
Brown, A;
Louisa, E;
Stuart, F;
Jamie, B;
Alison, F;
Lisa, M;
Duncan, R;
+ view all
(2020)
Supporting weight management services during the COVID-19 pandemic: Phase I insights.
Public Health England: London, UK.
|
C
Cavaillon, J-M;
Singer, M;
Skirecki, T;
(2020)
Sepsis therapies: learning from 30 years of failure of translational research to propose new leads.
EMBO Molecular Medicine
, 12
(4)
, Article e10128. 10.15252/emmm.201810128.
|
Chambers, ES;
Akbar, AN;
(2020)
Can blocking inflammation enhance immunity during aging?
Journal of Allergy and Clinical Immunology
, 145
(5)
pp. 1323-1331.
10.1016/j.jaci.2020.03.016.
|
Chen, DL;
Ballout, S;
Chen, L;
Cheriyan, J;
Choudhury, G;
Denis-Bacelar, AM;
Emond, E;
... Winkler, T; + view all
(2020)
Consensus recommendations on the use of ¹⁸F-FDG PET/CT in lung disease.
The Journal of Nuclear Medicine
10.2967/jnumed.120.244780.
|
Chin, MHW;
Gentleman, E;
Coppens, MO;
Day, RM;
(2020)
Rethinking Cancer Immunotherapy by Embracing and Engineering Complexity.
Trends in Biotechnology
, 38
(10)
pp. 1054-1065.
10.1016/j.tibtech.2020.05.003.
|
Chin, MHW;
Norman, MDA;
Gentleman, E;
Coppens, M-O;
Day, RM;
(2020)
A Hydrogel-Integrated Culture Device to Interrogate T Cell Activation with Physicochemical Cues.
ACS Applied Materials & Interfaces
, 12
(42)
pp. 47355-47367.
10.1021/acsami.0c16478.
|
Chouhan, MD;
Ramasawmy, R;
Bainbridge, A;
Campbell-Washburn, A;
Halligan, S;
Davies, N;
Walker-Samuel, S;
... Taylor, SA; + view all
(2020)
Liver perfusion MRI in a rodent model of cirrhosis: Agreement with bulk‐flow phase‐contrast MRI and noninvasive evaluation of inflammation in chronic liver disease using flow‐sensitive alternating inversion recovery arterial spin labelling and tissue T1.
NMR in Biomedicine
, Article e4423. 10.1002/nbm.4423.
(In press).
|
Chouhan, MD;
Taylor, SA;
Bainbridge, A;
Walker-Samuel, S;
Davies, N;
Halligan, S;
Lythgoe, MF;
(2020)
Haemodynamic changes in cirrhosis following terlipressin and induction of sepsis-a preclinical study using caval subtraction phase-contrast and cardiac MRI.
European Radiology
10.1007/s00330-020-07259-w.
|
Coelewij, L;
Waddington, K;
Robinson, G;
Chocano, E;
McDonnell, T;
Farinha, F;
Peng, J;
... Pineda-Torra, I; + view all
(2020)
Using serum metabolomics analysis to predict sub-clinical atherosclerosis in patients with SLE.
MedRxiv: Cold Spring Harbor, NY, USA.
|
Collins, G;
(2020)
Letter in response to: Coagulation markers are independent predictors of increased oxygen requirements and thrombosis in COVID-19.
Thrombosis and Haemostasis
, 18
(12)
pp. 3382-3384.
10.1111/jth.15080.
|
Collins, G;
Fleming, S;
Knight, C;
(2020)
After covid-19, the NHS cannot return to “business as usual”.
The BMJ Opinion
|
Collins, GB;
(2020)
Pragmatic Care in Cardiology: A New Transition Phase Between Curative and Palliative Care.
JACC: Case Reports
, 2
(14)
pp. 2278-2280.
10.1016/j.jaccas.2020.08.013.
|
Collins, GB;
Jenner, WJ;
Kaier, TE;
Bhattacharyya, S;
(2020)
COVID-19: A United Kingdom National Health Service cardiology perspective.
JACC: Case Reports
10.1016/j.jaccas.2020.04.024.
(In press).
|
Covre, LP;
De Maeyer, RPH;
Gomes, DCO;
Akbar, AN;
(2020)
The role of senescent T cells in immunopathology.
Aging Cell
, Article e13272. 10.1111/acel.13272.
(In press).
|
Covre, LP;
Devine, OP;
De Moura, RG;
Vukmanovic-Stejic, M;
Dietze, R;
Ribeiro-Rodrigues, R;
De Matos Guedes, HL;
... Oliveira Gomes, DC; + view all
(2020)
Compartmentalized cytotoxic immune response leads to distinct pathogenic roles of natural killer and senescent CD8⁺ T cells in human cutaneous leishmaniasis.
Immunology
, 159
(4)
pp. 429-440.
10.1111/imm.13173.
|
Crisóstomo, L;
Videira, RA;
Jarak, I;
Starčević, K;
Mašek, T;
Rato, LP;
Raposo, JF;
... Alves, MG; + view all
(2020)
Diet during early life defines testicular lipid content and sperm quality in adulthood.
American Journal of Physiology: Endocrinology and Metabolism
, 319
(6)
E1061-E1073.
10.1152/ajpendo.00235.2020.
|
D
Davies, TW;
Montgomery, H;
Gilbert-Kawai, E;
(2020)
Cannulation of the subclavian vein using real-time ultrasound guidance.
Journal of the Intensive Care Society
10.1177/1751143720901403.
(In press).
|
De Maeyer, R;
Van De Merwe, R;
Louie, R;
Bracken, O;
Devine, O;
Goldstein, D;
Uddin, M;
... Gilroy, D; + view all
(2020)
Blocking elevated p38 MAPK restores efferocytosis and inflammatory resolution in the elderly.
Nature Immunology
, 21
pp. 615-625.
10.1038/s41590-020-0646-0.
|
Desai, RA;
Davies, AL;
Del Rossi, N;
Tachrount, M;
Dyson, A;
Gustavson, B;
Kaynezhad, P;
... Smith, KJ; + view all
(2020)
Nimodipine reduces dysfunction and demyelination in models of multiple sclerosis.
Annals of Neurology
, 88
(1)
pp. 123-136.
10.1002/ana.25749.
|
Di Lorenzo, N;
Antoniou, SA;
Batterham, RL;
Busetto, L;
Godoroja, D;
Iossa, A;
Carrano, FM;
... Silecchia, G; + view all
(2020)
Clinical practice guidelines of the European Association for Endoscopic Surgery (EAES) on bariatric surgery: update 2020 endorsed by IFSO-EC, EASO and ESPCOP.
Surgical Endoscopy
, 34
pp. 2332-2358.
10.1007/s00464-020-07555-y.
|
Dorling, JL;
Thackray, AE;
King, JA;
Pucci, A;
Goltz, FR;
Batterham, RL;
Stensel, DJ;
(2020)
No Influence of the Fat Mass and Obesity-Associated Gene rs9939609 Single Nucleotide Polymorphism on Blood Lipids in Young Males.
Nutrients
, 12
(12)
, Article 3857. 10.3390/nu12123857.
|
Durham, T;
Zander, D;
Stomeo, N;
Minnion, M;
Hogarth, G;
Feelisch, M;
Singer, M;
(2020)
Chemistry, pharmacology, and cellular uptake mechanisms of thiometallate sulfide donors.
British Journal of Pharmacology
, 177
(4)
pp. 745-756.
10.1111/bph.14670.
|
E
Elwenspoek, MMC;
Jackson, J;
Dawson, S;
Everitt, H;
Gillett, P;
Hay, AD;
Jones, HE;
... Whiting, P; + view all
(2020)
Accuracy of potential diagnostic indicators for coeliac disease: a systematic review protocol.
BMJ Open
, 10
(10)
, Article e038994. 10.1136/bmjopen-2020-038994.
|
Emond, E;
Bousse, A;
Machado, M;
Porter, J;
Groves, A;
Hutton, B;
Thielemans, K;
(2020)
Effect of Attenuation Mismatches in Time of Flight PET Reconstruction.
Physics in Medicine & Biology
, 65
, Article 085009. 10.1088/1361-6560/ab7a6f.
|
Emond, EC;
Bousse, A;
Brusaferri, L;
Groves, AM;
Hutton, BF;
Thielemans, K;
(2020)
Mass Preservation for Respiratory Motion Registration in both PET and CT.
In:
Proceedings of the 2019 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC).
IEEE: Manchester, UK.
|
Evans, PG;
Sokolska, M;
Alves, A;
Harrison, IF;
Ohene, Y;
Nahavandi, P;
Ismail, O;
... Wells, JA; + view all
(2020)
Non-Invasive MRI of Blood-Cerebrospinal Fluid Barrier Function.
Nature Communications
, 11
(1)
, Article 2081. 10.1038/s41467-020-16002-4.
|
Evans, RDR;
Antonelou, M;
Sathiananthamoorthy, S;
Rega, M;
Henderson, S;
Ceron-Gutierrez, L;
Barcenas-Morales, G;
... Salama, AD; + view all
(2020)
Inherited salt-losing tubulopathies are associated with immunodeficiency due to impaired IL-17 responses.
Nature Communications
, 11
, Article 4368. 10.1038/s41467-020-18184-3.
|
F
Flint, SW;
Brown, A;
Tahrani, AA;
Piotrkowicz, A;
Joseph, A-C;
(2020)
Cross-sectional analysis to explore the awareness, attitudes and actions of UK adults at high risk of severe illness from COVID-19.
BMJ Open
, 10
(12)
, Article e045309. 10.1136/bmjopen-2020-045309.
|
Fox, TA;
Troy-Barnes, E;
Kirkwood, AA;
Chan, WY;
Day, JW;
Chavda, SJ;
Kumar, EA;
... Ardeshna, KM; + view all
(2020)
Response to 'Impact of immunosuppression on mortality in critically ill COVID-19 patients'.
British Journal of Haematology
, 191
(3)
pp. 505-506.
10.1111/bjh.17110.
|
Fox, TA;
Troy-Barnes, E;
Kirkwood, AA;
Chan, WY;
Day, J;
Chavda, SJ;
Kumar, EA;
... Ardeshna, KM; + view all
(2020)
Clinical outcomes and risk factors for severe COVID‐19 infection in patients with haematological disorders receiving chemo‐ or immunotherapy.
British Journal of Haematology
, 191
(2)
pp. 194-206.
10.1111/bjh.17027.
|
Fragkos, KC;
Bouroncle, MCP;
Kumar, S;
Caselton, L;
Menys, A;
Bainbridge, A;
Taylor, SA;
... Mehta, S; + view all
(2020)
Serum Scoring and Quantitative Magnetic Resonance Imaging in Intestinal Failure-Associated Liver Disease: A Feasibility Study.
Nutrients
, 12
(7)
, Article 2151. 10.3390/nu12072151.
|
G
Gendron, T;
Pereira, R;
Abdi, HY;
Witney, TH;
Årstad, E;
(2020)
Iron(II)/Persulfate Mediated Newman-Kwart Rearrangement.
Organic Letters
, 22
(1)
pp. 274-278.
10.1021/acs.orglett.9b04280.
|
Gentry-Maharaj, A;
Burnell, M;
Dilley, J;
Ryan, A;
Karpinskyj, C;
Gunu, R;
Mallett, S;
... Menon, U; + view all
(2020)
Serum HE4 and diagnosis of ovarian cancer in postmenopausal women with adnexal masses.
American Journal of Obstetrics and Gynecology
, 222
(1)
56.e1-56.e17.
10.1016/j.ajog.2019.07.031.
|
Gilroy, D;
Pereira, B;
De Maeyer, R;
covre, L;
Nehar-Belaid, D;
Lanna, A;
Ward, S;
... Akbar, A; + view all
(2020)
Sestrins induce natural killer function in senescent-like CD8+ T cells.
Nature Immunology
, 21
pp. 684-694.
10.1038/s41590-020-0643-3.
|
Gilroy, DW;
De Maeyer, RPH;
Tepper, M;
O'Brien, A;
Uddin, M;
Chen, J;
Goldstein, DR;
(2020)
Treating exuberant, non-resolving inflammation in the lung; Implications for acute respiratory distress syndrome and COVID-19.
Pharmacology & Therapeutics
, Article 107745. 10.1016/j.pharmthera.2020.107745.
(In press).
|
H
Halligan, S;
Kenis, SF;
Abeyakoon, O;
Plumb, AAO;
Mallett, S;
(2020)
How to avoid describing your radiological research study incorrectly.
European Radiology
10.1007/s00330-020-06720-0.
(In press).
|
Harrison, IF;
Ismail, O;
Machhada, A;
Colgan, N;
Ohene, Y;
Nahavandi, P;
Ahmed, Z;
... Lythgoe, MF; + view all
(2020)
Impaired glymphatic function and clearance of tau in an Alzheimer's disease model.
Brain
, 143
pp. 2576-2593.
10.1093/brain/awaa179.
|
Hazlehurst, JM;
Logue, J;
Parretti, HM;
Abbott, S;
Brown, A;
Pournaras, DJ;
Tahrani, AA;
(2020)
Developing Integrated Clinical Pathways for the Management of Clinically Severe Adult Obesity: a Critique of NHS England Policy.
Current Obesity Reports
, 9
pp. 530-543.
10.1007/s13679-020-00416-8.
|
Hendow, EK;
Moazen, M;
Iacoviello, F;
Bozec, L;
Pellet-Many, C;
Day, RM;
(2020)
Microporous Biodegradable Films Promote Therapeutic Angiogenesis.
Advanced Healthcare Materials
, Article 2000806. 10.1002/adhm.202000806.
(In press).
|
K
Kang, L;
Zhang, X;
Ji, L;
Kou, T;
Smith, SM;
Zhao, B;
Guo, X;
... Hu, X; + view all
(2020)
The colonic macrophage transcription factor RBP-J orchestrates intestinal immunity against bacterial pathogens.
The Journal of Experimental Medicine
, 217
(4)
, Article e20190762. 10.1084/jem.20190762.
|
Kasivisvanathan, V;
Lindsay, J;
Rakshani-Moghadam, S;
Elhamshary, A;
Kapriniotis, K;
Kazantzis, G;
Syed, B;
... UCLH study group collaborators; + view all
(2020)
A cohort study of 30 day mortality after NON-EMERGENCY surgery in a COVID-19 cold site.
International Journal of Surgery
, 84
pp. 57-65.
10.1016/j.ijsu.2020.10.019.
|
Khadhouri, S;
Gallagher, KM;
MacKenzie, K;
Shah, TT;
Gao, C;
Moore, S;
Zimmermann, E;
... IDENTIFY Protocol Collaborators Group, .; + view all
(2020)
IDENTIFY: The investigation and detection of urological neoplasia in patients referred with suspected urinary tract cancer: A multicentre cohort study.
International Journal of Surgery Protocols
, 21
pp. 8-12.
10.1016/j.isjp.2020.02.002.
|
Khaliq, W;
Grossmann, P;
Neugebauer, S;
Kleyman, A;
Domizi, R;
Calcinaro, S;
Brealey, D;
... Bauer, M; + view all
(2020)
Lipid metabolic signatures deviate in sepsis survivors compared to non-survivors.
Computational and Structural Biotechnology Journal
, 18
pp. 3678-3691.
10.1016/j.csbj.2020.11.009.
|
Khoshnevis, M;
Carozzo, C;
Brown, R;
Bardies, M;
Bonnefont-Rebeix, C;
Belluco, S;
Nennig, C;
... Ponce, F; + view all
(2020)
Feasibility of intratumoral(165)Holmium siloxane delivery to induced U87 glioblastoma in a large animal model, the Yucatan minipig.
PLOS ONE
, 15
(6)
, Article e0234772. 10.1371/journal.pone.0234772.
|
Krehl, L-M;
Plumb, JOM;
Wachsmuth, NB;
Haupt, S;
Kumar, SB;
Otto, JM;
Schierbauer, J;
... Schmidt, WFJ; + view all
(2020)
A carbon monoxide ‘single breath’ method to measure total haemoglobin mass: a feasibility study.
Experimental Physiology
10.1113/EP089076.
(In press).
|
L
Lacey, J;
Corbett, J;
Shepherd, A;
Dubois, A;
Hughes, F;
White, D;
Tipton, M;
... Montgomery, H; + view all
(2020)
Thirst-guided participant-controlled intravenous fluid rehydration: a single blind, randomised crossover study.
British Journal of Anaesthesia
, 124
(4)
pp. 403-410.
10.1016/j.bja.2019.12.008.
|
Lipman, M;
Chambers, RC;
Singer, M;
Brown, JS;
(2020)
SARS-CoV-2 pandemic: clinical picture of COVID-19 and implications for research.
Thorax
10.1136/thoraxjnl-2020-215024.
(In press).
|
Little, CD;
Kotecha, T;
Candilio, L;
Jabbour, RJ;
Collins, GB;
Ahmed, A;
Connolly, M;
... Rakhit, R; + view all
(2020)
COVID-19 pandemic and STEMI: pathway activation and outcomes from the pan-London heart attack group.
Open Heart
, 7
(2)
, Article e001432. 10.1136/openhrt-2020-001432.
|
M
Ma, D;
Cardoso, MJ;
Zuluaga, MA;
Modat, M;
Powell, NM;
Wiseman, FK;
Cleary, JO;
... Ourselin, SE; + view all
(2020)
Substantially thinner internal granular layer and reduced molecular layer surface in the cerebellar cortex of the Tc1 mouse model of down syndrome – a comprehensive morphometric analysis with active staining contrast-enhanced MRI.
NeuroImage
, 223
, Article 117271. 10.1016/j.neuroimage.2020.117271.
|
Madrigal-Garcia, MI;
Archer, D;
Singer, M;
Rodrigues, M;
Shenfield, A;
Moreno-Cuesta, J;
(2020)
Do Temporal Changes in Facial Expressions Help Identify Patients at Risk of Deterioration in Hospital Wards? A Post Hoc Analysis of the Visual Early Warning Score Study.
Critical Care Explorations
, 2
(5)
, Article e0115. 10.1097/CCE.0000000000000115.
|
Makaronidis, J;
Mok, J;
Balogun, N;
Magee, CG;
Omar, RZ;
Carnemolla, A;
Batterham, RL;
(2020)
Seroprevalence of SARS-CoV-2 antibodies in people with an acute loss in their sense of smell and/or taste in a community-based population in London, UK: An observational cohort study.
PLOS Medicine
, 17
(10)
, Article e1003358. 10.1371/journal.pmed.1003358.
|
Mallett, S;
Allen, J;
Graziadio, S;
Taylor, SA;
Sakai, NS;
Green, K;
Suklan, J;
... Halligan, S; + view all
(2020)
At what times during infection is SARS-CoV-2 detectable and no longer detectable using RT-PCR based tests?: A systematic review of individual participant data.
MedRxiv: Ithaca, NY, USA.
|
Mallett, S;
Allen, AJ;
Graziadio, S;
Taylor, SA;
Sakai, NS;
Green, K;
Suklan, J;
... Halligan, S; + view all
(2020)
At what times during infection is SARS-CoV-2 detectable and no longer detectable using RT-PCR-based tests? A systematic review of individual participant data.
BMC Medicine
, 18
, Article 346. 10.1186/s12916-020-01810-8.
|
Mallett, S;
Rick, C;
Brown, J;
Ottridge, R;
Palmer, A;
Parker, V;
Priest, L;
(2020)
Test evaluation trials present different challenges for trial managers compared to Intervention trials.
Trials
, 21
, Article 987. 10.1186/s13063-020-04861-7.
|
Manson, JJ;
Crooks, C;
Naja, M;
Ledlie, A;
Goulden, B;
Liddle, T;
Khan, E;
... Tattersall, RS; + view all
(2020)
COVID-19-associated hyperinflammation and escalation of patient care: a retrospective longitudinal cohort study.
The Lancet Rheumatology
, 2
(10)
e594-e602.
10.1016/S2665-9913(20)30275-7.
|
Marina, N;
Christie, IN;
Korsak, A;
Doronin, M;
Brazhe, A;
Hosford, PS;
Wells, JA;
... Gourine, AV; + view all
(2020)
Astrocytes monitor cerebral perfusion and control systemic circulation to maintain brain blood flow.
Nature Communications
, 11
, Article 131. 10.1038/s41467-019-13956-y.
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